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Polynucleotides

Discover the transformative power of Polynucleotides, an advanced injectable treatment designed to stimulate skin repair and regeneration using DNA fragments. This cutting-edge treatment enhances skin quality, boosts elasticity, reduces fine lines, addresses scarring, evens pigmentation, and more.

Derived from naturally occurring biocompatible molecules, Polynucleotides mimic human DNA, making them highly compatible with your skin cells. These molecules play a crucial role in producing collagen, elastin — key proteins that maintain youthful skin. Over time, the natural depletion of these components leads to fine lines, pigmentation, and skin laxity. By reintroducing Polynucleotides into the skin, we accelerate cell turnover to boost collagen and elastin production, restoring your skin’s vitality.

Particularly effective for rejuvenating the under-eye area, Polynucleotides also work wonders on the neck, cheeks, décolletage, and lower face, delivering comprehensive skin revitalisation.

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Client Results:

Before and after Polynucleotides under the eyes by our Level 7 Advanced Aesthetic Nurse Prescriber, Ashley.

Treatment Benefits:

Improves Skin Elasticity

Polynucleotides stimulate collagen production, helping to restore firmness and improve skin’s elasticity, reducing sagging and signs of ageing.
Natural Skin Repair

By promoting cell regeneration, Polynucleotides help repair damaged skin tissues, improving overall skin health and resilience.
Bio Stimulation

By interacting with cellular DNA, Polynucleotides promote the release of growth factors, which enhance the skin’s natural regenerative processes, improving hydration, texture, and tone.
Reduction of Fine Lines and Wrinkles

Softens fine lines and wrinkles by rejuvenating the skin structure and texture, leaving a youthful and refreshed look.
Enhanced Fibroblast Activity

Polynucleotides interact with DNA to stimulate fibroblasts—the cells responsible for producing collagen and elastin—key proteins that maintain skin elasticity and firmness.
DNA Repair and Protection

Polynucleotides help repair damaged DNA within skin cells, counteracting the effects of environmental stressors like UV radiation and pollution. This process restores cellular function and improves skin resilience over time.
Improved Skin Tone and Texture

Polynucleotides work to even out skin tone and refine texture, giving you a smoother and more luminous complexion.
Stimulation of Cellular Renewal

By activating natural repair mechanisms, Polynucleotides boost the turnover of skin cells, helping to replace damaged cells with healthy ones for a revitalised complexion.
Deep Hydration

Polynucleotide treatment boosts moisture retention in the skin, providing long-lasting hydration for a plump, dewy appearance.

Client Results

Areas we can treat with
Polynucleotides:

Under-Eye Area: To reduce dark circles, fine lines, and puffiness by improving skin hydration and elasticity.
Face: To restore volume, improve skin texture and soften lines. Particularly beneficial for cheeks, nasolabial folds, around the mouth and jawline.
Neck and Décolletage: To improve elasticity, rejuvenate the skin and reduce crepey skin.
Body Areas: To improve skin firmness and elasticity in areas prone to sagging, such as the knees, elbows and hands.
Stretch Marks & Scarring: To improve the appearance of stretch marks and scars by enhancing skin regeneration and accelerate healing
Post-Acne Marks: To promote even skin tone and texture.

The India Gabrielle Clinic - Aesthetics - Permanent Makeup - Laser - Skin - Bexhill, East Sussex - Reception Area

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“Fantastic service. Rare to find someone who you can trust completely and knows their stuff. She is a lovely person and takes the time to perfect her results. Also it was such a lovely and clean establishment. Highly recommended. ”

Emma O'Donnell
"Kind and professional, really take the time to talk to you to make sure you get the best results. Everything is explained clearly both beforehand and after."

Emma Morley
"Great results ! And lovely staff will be returning with other treatments . Thank you ! "

Tara Burt
“India Gabrielle are definitely five stars and offer a very personal and tailored treatment plan . They explain everything and put you very much at ease . I would highly recommend this business to anyone looking for quality treatment from top therapists.”

Sharron Griffin
"I am so delighted to have been recommended India. After two very bad previous experiences elsewhere I was very relieved to find someone who is so professional and patient. Her attention to detail and talent is utterly incredible. I feel completely safe under her care and trust her implicitly."

Jo Sheffield

- Stay Hydrated: Drink 3 litres of water in the 3 days leading up to treatment. Hydration is crucial to obtaining a good result!
- Avoid Blood Thinners: Refrain from taking blood-thinning medications or supplements (e.g., aspirin, ibuprofen, fish oil, vitamin E, or gingko biloba) for at least 3-7 days before treatment to reduce the risk of bruising. Consult your doctor before stopping any prescription medications.
- Alcohol and Caffeine: Avoid alcohol and caffeine for at least 24-48 hours before the procedure as they can increase the risk of swelling and bruising.
- Skin Health: Ensure the treatment area is free of active skin infections, cold sores, rashes, or open wounds. If you have a history of cold sores, notify your practitioner in advance.
- Avoid Other Treatments: Refrain from having chemical peels, laser treatments, or other cosmetic procedures on the treatment area for at least 2-3 weeks before your session.
- Plan Around Events: Schedule the treatment with enough time (at least 1-2 weeks) before any major events to allow for any potential side effects such as redness, bruising, or swelling to subside.
- Wear SPF: Do use sunscreen pre-and-post treatment to protect your skin. We will not be able to treat you if you have sunburnt skin.
- Arrive Makeup-Free: If possible please arrive without makeup on the area/s to be treated.
- Reschedule If Unwell: You MUST be fit and well for at least 2 weeks before receiving this treatment. We cannot treat you if you are currently unwell or if you have recently been unwell. This includes any type of infection or antibiotics. If this applies to you - please call the clinic as soon as possible to reschedule your appointment.
- Avoid Touching the Area: Refrain from touching, massaging, or applying pressure to the treated area for at least 24 hours. This helps prevent infection and allows the product to settle properly.
- No Makeup for 24 Hours: Avoid applying makeup or skincare products to the treated area for the first 24 hours to minimise the risk of irritation or infection.
- Stay Hydrated: Drink plenty of water to keep your skin hydrated and optimize the effects of the treatment.
- Avoid Extreme Temperatures: Refrain from hot showers, saunas, steam rooms, or intense exercise that causes sweating for 24-48 hours, as heat can exacerbate swelling and bruising.
- Avoid Alcohol and Caffeine: Limit alcohol and caffeine consumption for 24-48 hours post-treatment, as they can increase swelling and delay the healing process.
- Avoid Sun Exposure: Stay out of direct sunlight and avoid tanning beds for at least a week after treatment. Use sunscreen with a high SPF to protect the skin and prevent pigmentation changes.
- Manage Swelling and Bruising: Mild swelling, bruising, and redness are common after treatment and should subside within a few days. You can apply a sterile cold compress gently to the area to reduce swelling. Arnica cream or tablets may help speed up the healing of bruising.
- No Other Treatments: Avoid any other facial treatments (such as facials, chemical peels, or laser therapy) for at least 2 weeks to allow your skin to heal properly.

FAQs

The number of sessions varies based on your skin’s condition and desired results. Most clients benefit from 3–4 sessions spaced a few weeks apart, with maintenance sessions every 6–12 months to sustain results.
Polynucleotides are natural molecules derived from DNA that stimulate skin regeneration and repair. They enhance cellular turnover, boost collagen production, and improve hydration, resulting in healthier and more youthful-looking skin.
This treatment is effective for a wide range of concerns, including fine lines, wrinkles, loss of elasticity, uneven skin tone, dehydrated skin, and signs of ageing. It also promotes skin repair and healing so is an excellent choice for post-acne marks, scarring and stretch marks.
The treatment involves injecting Polynucleotide solutions into the skin using fine needles. It is minimally invasive, with most sessions taking between 30–60 minutes, depending on the treatment area.
We start with a consultation to assess your suitability for the treatment and discuss your goals before thoroughly cleansing the area and applying a topical anaesthetic to numb the area. After the procedure, your practitioner will provide guidance on aftercare.
Most clients experience minimal discomfort during the procedure. The treatment involves a series of small injections, and a numbing cream is applied to reduce discomfort.
Results from Polynucleotide Injections can often be seen within a few weeks as your skin begins to regenerate and improve. Full results typically develop over the course of 4–6 weeks as collagen production and repair processes are stimulated.
Polynucleotide treatments have minimal downtime. Some redness, swelling, or mild bruising may occur at the injection sites, but these typically subside within a few days.
Yes, it is often combined with treatments like Radiofrequency Microneedling, Microneedling, Dermal Fillers, Skin Boosters or Laser Skin Rejuvenation. Your practitioner can create a tailored treatment plan based on your specific needs.
The results typically last 6–12 months, depending on individual factors like skin type, age, and lifestyle. Maintenance sessions can help prolong the benefits.